1OS5
Crystal structure of HCV NS5B RNA polymerase complexed with a novel non-competitive inhibitor.
Summary for 1OS5
Entry DOI | 10.2210/pdb1os5/pdb |
Descriptor | Hepatitis C virus NS5B RNA polymerase, 3-(4-AMINO-2-TERT-BUTYL-5-METHYL-PHENYLSULFANYL)-6-CYCLOPENTYL-4-HYDROXY-6-[2-(4-HYDROXY-PHENYL)-ETHYL]-5,6-DIHYDRO-PYRAN-2-ONE (3 entities in total) |
Functional Keywords | enzyme-inhibitor complex, transferase |
Biological source | Hepatitis C virus |
Total number of polymer chains | 1 |
Total formula weight | 64658.13 |
Authors | Love, R.A.,Parge, H.E.,Yu, X.,Hickey, M.J.,Diehl, W.,Gao, J.,Wriggers, H.,Ekker, A.,Wang, L.,Thomson, J.A.,Dragovich, P.S.,Fuhrman, S.A. (deposition date: 2003-03-18, release date: 2004-03-18, Last modification date: 2024-04-03) |
Primary citation | Love, R.A.,Parge, H.E.,Yu, X.,Hickey, M.J.,Diehl, W.,Gao, J.,Wriggers, H.,Ekker, A.,Wang, L.,Thomson, J.A.,Dragovich, P.S.,Fuhrman, S.A. Crystallographic identification of a noncompetitive inhibitor binding site on the hepatitis C virus NS5B RNA polymerase enzyme. J.Virol., 77:7575-7581, 2003 Cited by PubMed: 12805457DOI: 10.1128/JVI.77.13.7575-7581.2003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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