Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1OI0

CRYSTAL STRUCTURE OF AF2198, A JAB1/MPN DOMAIN PROTEIN FROM ARCHAEOGLOBUS FULGIDUS

Summary for 1OI0
Entry DOI10.2210/pdb1oi0/pdb
DescriptorHYPOTHETICAL PROTEIN AF2198, ZINC ION, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM, ... (4 entities in total)
Functional Keywordsproteasome, deubiquitination, archaea, hydrolase
Biological sourceARCHAEOGLOBUS FULGIDUS
Total number of polymer chains4
Total formula weight55969.62
Authors
Tran, H.J.T.T.,Allen, M.D.,Lowe, J.,Bycroft, M. (deposition date: 2003-06-04, release date: 2003-08-14, Last modification date: 2024-10-16)
Primary citationTran, H.J.T.T.,Allen, M.D.,Lowe, J.,Bycroft, M.
The Structure of the Jab1/Mpn Domain and its Implications for Proteasome Function
Biochemistry, 42:11460-, 2003
Cited by
PubMed Abstract: The 26S proteasome is responsible for the degradation of polyubiquitinated proteins. During this process the polyubiquitin chain is removed. The identity of the proteasomal component that is responsible for this activity has not been clear, as it contains no subunits that resemble known deubiquitinating enzymes. The Jab1/MPN domain is a widespread 120 amino acid protein module found in archaea, bacteria, and eukaryotes. In eukaryotes the Jab1/MPN domain is found in subunits of several multiprotein complexes including the proteasome. Recently it has been proposed that the Jab1/MPN domain of the proteasomal subunit Rpn11 is responsible for the removal of the polyubiquitin chain from substrate proteins. Here we report the crystal structure and characterization of AF2198, a Jab1/MPN domain protein from Archaeoglobolus fulgidus. The structure reveals a fold that resembles that of cytidine deaminase and places the Jab1/MPN domain in a superfamily of metal dependent hydrolases.
PubMed: 14516197
DOI: 10.1021/BI035033G
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation

226707

PDB entries from 2024-10-30

PDB statisticsPDBj update infoContact PDBjnumon