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1N83

Crystal Structure of the complex between the Orphan Nuclear Hormone Receptor ROR(alpha)-LBD and Cholesterol

Summary for 1N83

DescriptorNuclear receptor ROR-alpha
Functional Keywordsthree-layered alpha helical sandwich, receptor, transcription regulation, nuclear protein, DNA binding, LIPID BINDING PROTEIN,LIPID BINDING PROTEIN
Biological sourceHomo sapiens (human)
Cellular locationNucleus 
Organ source
Total number of polymer chains1
Total molecular weight31901.19
Authors
Kallen, J.A.,Schlaeppi, J.M.,Bitsch, F.,Geisse, S.,Geiser, M.,Delhon, I.,Fournier, B. (deposition date: 2002-11-19, release date: 2002-12-11, modification date: 2009-02-24)
Primary citation
Kallen, J.A.,Schlaeppi, J.M.,Bitsch, F.,Geisse, S.,Geiser, M.,Delhon, I.,Fournier, B.
X-ray Structure of hROR(alpha) LBD at 1.63A: Structural and Functional data that Cholesterol or a Cholesterol derivative is the natural ligand of ROR(alpha)
Structure, 10:1697-1702, 2002
PubMed: 12467577
DOI: 10.1016/S0969-2126(02)00912-7
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.63 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.228900.4%6.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolutionDownload full validation report

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rotated about y axis by 90°
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entries available on 2014-10-15
00:00 UTC / 09:00 JST