1MVC

Crystal structure of the human RXR alpha ligand binding domain bound to the synthetic agonist compound BMS 649 and a coactivator peptide

Summary for 1MVC

• Entry DOI: 10.2210/pdb1mvc/pdb
• Related: 1FBY 1MV9
• Descriptor: RXR retinoid X receptor, Nuclear receptor coactivator 2, 4-[2-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRO-NAPHTHALEN-2-YL)-[1,3]DIOXOLAN-2-YL]-BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: nuclear receptor, retinoic acid, agonist recognition, transcription factor, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 28815.37

Authors

Egea, P.F.,Mitschler, A.,Moras, D. (deposition date: 2002-09-24, release date: 2002-10-16, Last modification date: 2023-10-25)

• Primary citation: Egea, P.F.,Mitschler, A.,Moras, D.; Molecular Recognition of Agonist Ligands by RXRs; MOL.ENDOCRINOL., 16:987-997, 2002; PubMed: 11981034; DOI: 10.1210/me.16.5.987

Experimental method

X-RAY DIFFRACTION (1.9 Å)