1MOE
The three-dimensional structure of an engineered scFv T84.66 dimer or diabody in VL to VH linkage.
Summary for 1MOE
Entry DOI | 10.2210/pdb1moe/pdb |
Descriptor | anti-CEA mAb T84.66, SULFATE ION (3 entities in total) |
Functional Keywords | anti carcinoembryonic antigen, t84.66, diabody, dimer, scfv, variable domain, immune system |
Biological source | Mus musculus (house mouse) More |
Total number of polymer chains | 2 |
Total formula weight | 51919.43 |
Authors | Carmichael, J.A.,Power, B.E.,Garrett, T.P.J.,Yazaki, P.J.,Shively, J.E.,Raubischek, A.A.,Wu, A.M.,Hudson, P.J. (deposition date: 2002-09-09, release date: 2003-03-18, Last modification date: 2023-10-25) |
Primary citation | Carmichael, J.A.,Power, B.E.,Garrett, T.P.,Yazaki, P.J.,Shively, J.E.,Raubischek, A.A.,Wu, A.M.,Hudson, P.J. The Crystal Structure of an Anti-CEA scFv Diabody Assembled from T84.66 scFvs in VL-to-VH Orientation: Implications for Diabody Flexibility J.Mol.Biol., 326:341-351, 2003 Cited by PubMed: 12559905DOI: 10.1016/S0022-2836(02)01428-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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