1M8O

Platelet integrin alfaIIb-beta3 cytoplasmic domain

Summary for 1M8O

Entry DOI	10.2210/pdb1m8o/pdb
Descriptor	platelet integrin alfaIIb subunit: cytoplasmic domain, platelet integrin beta3 subunit: cytoplasmic domain (2 entities in total)
Functional Keywords	alfa helix, platelet, membrane protein
Biological source	Homo sapiens (human) More
Cellular location	Membrane; Single-pass type I membrane protein: P08514 P05106
Total number of polymer chains	2
Total formula weight	7981.85
Authors	Vinogradova, O.,Velyvis, A.,Velyviene, A.,Hu, B.,Haas, T.,Plow, E.F.,Qin, J. (deposition date: 2002-07-25, release date: 2002-09-18, Last modification date: 2022-02-23)
Primary citation	Vinogradova, O.,Velyvis, A.,Velyviene, A.,Hu, B.,Haas, T.A.,Plow, E.F.,Qin, J. A Structural mechanism of integrin alfaiib beta3 "Inside-out" Activation as regulated by its cytoplasmic face. Cell(Cambridge,Mass.), 110:587-597, 2002 Cited by PubMed: 12230976 DOI: 10.1016/S0092-8674(02)00906-6 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation