1M7Q
Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor
Summary for 1M7Q
Entry DOI | 10.2210/pdb1m7q/pdb |
Descriptor | Mitogen-activated protein kinase 14, SULFATE ION, 1-(2,6-DICHLOROPHENYL)-5-(2,4-DIFLUOROPHENYL)-7-PIPERAZIN-1-YL-3,4-DIHYDROQUINAZOLIN-2(1H)-ONE, ... (4 entities in total) |
Functional Keywords | serine/threonine kinase, atp-binding domain, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 42584.35 |
Authors | Stelmach, J.E.,Liu, L.,Patel, S.B.,Pivnichny, J.V.,Scapin, G.,Singh, S.,Hop, C.E.C.A.,Wang, Z.,Cameron, P.M.,Nichols, E.A.,O'Keefe, S.J.,O'Neill, E.A.,Schmatz, D.M.,Schwartz, C.D.,Thompson, C.M.,Zaller, D.M.,Doherty, J.B. (deposition date: 2002-07-22, release date: 2002-12-11, Last modification date: 2024-02-14) |
Primary citation | Stelmach, J.E.,Liu, L.,Patel, S.B.,Pivnichny, J.V.,Scapin, G.,Singh, S.,Hop, C.E.,Wang, Z.,Strauss, J.R.,Cameron, P.M.,Nichols, E.A.,O'Keefe, S.J.,O'Neill, E.A.,Schmatz, D.M.,Schwartz, C.D.,Thompson, C.M.,Zaller, D.M.,Doherty, J.B. Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase. Bioorg.Med.Chem.Lett., 13:277-280, 2003 Cited by PubMed: 12482439DOI: 10.1016/S0960-894X(02)00752-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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