1M0E
ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASE
Summary for 1M0E
Entry DOI | 10.2210/pdb1m0e/pdb |
Related | 9MHT |
Descriptor | 5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', 5'-D(P*GP*TP*CP*AP*GP*(Z)P*GP*CP*AP*TP*GP*G)-3', Modification methylase HhaI, ... (5 entities in total) |
Functional Keywords | protein-dna covalent complex, mechanism based dna methylation inhibitors, zebularine, transferase-dna complex, transferase/dna |
Biological source | Haemophilus haemolyticus |
Total number of polymer chains | 3 |
Total formula weight | 44738.39 |
Authors | Zhou, L.,Cheng, X.,Connolly, B.A.,Dickman, M.J.,Hurd, P.J.,Hornby, D.P. (deposition date: 2002-06-12, release date: 2002-09-18, Last modification date: 2011-07-13) |
Primary citation | Zhou, L.,Cheng, X.,Connolly, B.A.,Dickman, M.J.,Hurd, P.J.,Hornby, D.P. ZEBULARINE: A NOVEL DNA METHYLATION INHIBITOR THAT FORMS A COVALENT COMPLEX WITH DNA METHYLTRANSFERASES J.MOL.BIOL., 321:591-599, 2002 Cited by PubMed: 12206775DOI: 10.1016/S0022-2836(02)00676-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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