1LMW

LMW U-PA Structure complexed with EGRCMK (GLU-GLY-ARG Chloromethyl Ketone)

Summary for 1LMW

Entry DOI	10.2210/pdb1lmw/pdb
Related PRD ID	PRD_000288
Descriptor	UROKINASE-TYPE PLASMINOGEN ACTIVATOR, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide (3 entities in total)
Functional Keywords	fibrinolysis, trypsin-like serine protease, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P00749 P00749
Total number of polymer chains	4
Total formula weight	63164.99
Authors	Spraggon, G.S.,Phillips, C.,Nowak, U.K.,Ponting, C.P.,Saunders, D.,Dobson, C.M.,Stuart, D.I.,Jones, E.Y. (deposition date: 1995-07-26, release date: 1996-01-29, Last modification date: 2013-02-27)
Primary citation	Spraggon, G.,Phillips, C.,Nowak, U.K.,Ponting, C.P.,Saunders, D.,Dobson, C.M.,Stuart, D.I.,Jones, E.Y. The crystal structure of the catalytic domain of human urokinase-type plasminogen activator. Structure, 3:681-691, 1995 Cited by PubMed: 8591045 DOI: 10.1016/S0969-2126(01)00203-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation