1LJT

Crystal Structure of Macrophage Migration Inhibitory Factor complexed with (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole-acetic acid methyl ester (ISO-1)

Summary for 1LJT

Entry DOI	10.2210/pdb1ljt/pdb
Descriptor	Macrophage migration inhibitory factor, 3-(4-HYDROXYPHENYL)-4,5-DIHYDRO-5-ISOXAZOLE-ACETIC ACID METHYL ESTER (3 entities in total)
Functional Keywords	protein-inhibitor complex, immune system
Biological source	Homo sapiens (human)
Cellular location	Secreted: P14174
Total number of polymer chains	3
Total formula weight	37770.88
Authors	Lubetsky, J.B.,Dios, A.,Han, J.,Aljabari, B.,Ruzsicska, B.,Mitchell, R.,Lolis, E.,Al-Abed, Y. (deposition date: 2002-04-22, release date: 2002-11-27, Last modification date: 2024-02-14)
Primary citation	Lubetsky, J.B.,Dios, A.,Han, J.,Aljabari, B.,Ruzsicska, B.,Mitchell, R.,Lolis, E.,Al-Abed, Y. The Tautomerase Active Site of Macrophage Migration Inhibitory factor is a Potential Target for Discovery of Novel Anti-inflammatory Agents J.Biol.Chem., 277:24976-24982, 2002 Cited by PubMed: 11997397 DOI: 10.1074/jbc.M203220200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation