1KZ8

CRYSTAL STRUCTURE OF PORCINE FRUCTOSE-1,6-BISPHOSPHATASE COMPLEXED WITH A NOVEL ALLOSTERIC-SITE INHIBITOR

Summary for 1KZ8

Entry DOI	10.2210/pdb1kz8/pdb
Descriptor	FRUCTOSE-1,6-BISPHOSPHATASE, 6-O-phosphono-beta-D-fructofuranose, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywords	hydrolase
Biological source	Sus scrofa (pig)
Total number of polymer chains	2
Total formula weight	75576.12
Authors	Wright, S.W.,Carlo, A.A.,Carty, M.D.,Danley, D.E.,Hageman, D.L.,Karam, G.A.,Levy, C.B.,Mansour, M.N.,Mathiowetz, A.M.,McClure, L.D.,Nestor, N.B.,McPherson, R.K.,Pandit, J.,Pustilnik, L.R.,Schulte, G.K.,Soeller, W.C.,Treadway, J.L.,Wang, I.-K.,Bauer, P.H. (deposition date: 2002-02-06, release date: 2002-10-16, Last modification date: 2023-08-16)
Primary citation	Wright, S.W.,Carlo, A.A.,Carty, M.D.,Danley, D.E.,Hageman, D.L.,Karam, G.A.,Levy, C.B.,Mansour, M.N.,Mathiowetz, A.M.,McClure, L.D.,Nestor, N.B.,McPherson, R.K.,Pandit, J.,Pustilnik, L.R.,Schulte, G.K.,Soeller, W.C.,Treadway, J.L.,Wang, I.-K.,Bauer, P.H. ANILINOQUINAZOLINE INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE BIND AT A NOVEL ALLOSTERIC SITE: SYNTHESIS, IN VITRO CHARACTERIZATION, AND X-RAY CRYSTALLOGRAPHY J.MED.CHEM., 45:3865-3877, 2002 Cited by PubMed: 12190310 DOI: 10.1021/jm010496a PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation