1KW0
Catalytic Domain of Human Phenylalanine Hydroxylase (Fe(II)) in Complex with Tetrahydrobiopterin and Thienylalanine
Summary for 1KW0
Entry DOI | 10.2210/pdb1kw0/pdb |
Related | 1DMW 1J8T 1J8U 1PAH 2PAH |
Descriptor | Phenylalanine-4-hydroxylase, FE (II) ION, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (5 entities in total) |
Functional Keywords | basket-arrangement 13 alpha-helices and 6 beta-strands, ferrous iron, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 38069.88 |
Authors | Andersen, O.A.,Flatmark, T.,Hough, E. (deposition date: 2002-01-28, release date: 2003-01-28, Last modification date: 2023-08-16) |
Primary citation | Andersen, O.A.,Flatmark, T.,Hough, E. Crystal Structure of the Ternary Complex of the Catalytic Domain of Human Phenylalanine Hydroxylase with Tetrahydrobiopterin and 3-(2-thienyl)-L-alanine, and its Implications for the Mechanism of Catalysis and Substrate Activation J.Mol.Biol., 320:1095-1108, 2002 Cited by PubMed: 12126628DOI: 10.1016/S0022-2836(02)00560-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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