1KFX
Crystal Structure of Human m-Calpain Form I
Summary for 1KFX
Entry DOI | 10.2210/pdb1kfx/pdb |
Related | 1KFU |
Descriptor | M-CALPAIN LARGE SUBUNIT, M-CALPAIN SMALL SUBUNIT (3 entities in total) |
Functional Keywords | regulation, papain-like, thiol-protease, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm: P17655 Cytoplasm (By similarity): P04632 |
Total number of polymer chains | 2 |
Total formula weight | 101231.88 |
Authors | Strobl, S.,Fernandez-Catalan, C.,Braun, M.,Huber, R.,Masumoto, H.,Nakagawa, K.,Irie, A.,Sorimachi, H.,Bourenkow, G.,Bartunik, H.,Suzuki, K.,Bode, W. (deposition date: 2001-11-23, release date: 2001-12-07, Last modification date: 2023-08-16) |
Primary citation | Strobl, S.,Fernandez-Catalan, C.,Braun, M.,Huber, R.,Masumoto, H.,Nakagawa, K.,Irie, A.,Sorimachi, H.,Bourenkow, G.,Bartunik, H.,Suzuki, K.,Bode, W. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium. Proc.Natl.Acad.Sci.USA, 97:588-592, 2000 Cited by PubMed: 10639123DOI: 10.1073/pnas.97.2.588 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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