1JCS
CRYSTAL STRUCTURE OF RAT PROTEIN FARNESYLTRANSFERASE COMPLEXED WITH THE PEPTIDE SUBSTRATE TKCVFM AND AN ANALOG OF FARNESYL DIPHOSPHATE
Summary for 1JCS
Entry DOI | 10.2210/pdb1jcs/pdb |
Related | 1D8D 1FT1 1JCQ 1JCR |
Descriptor | PROTEIN FARNESYLTRANSFERASE, ALPHA SUBUNIT, PROTEIN FARNESYLTRANSFERASE, BETA SUBUNIT, SYNTHETIC HEXAPEPTIDE TKCVFM, ... (7 entities in total) |
Functional Keywords | ftase, pft, pftase, ft, fpt, farnesyltransferase, farnesyl transferase, farnesyl protein transferase, caax, ras, cancer, inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Norway rat) More |
Total number of polymer chains | 3 |
Total formula weight | 94094.28 |
Authors | Long, S.B.,Casey, P.J.,Beese, L.S. (deposition date: 2001-06-11, release date: 2001-11-02, Last modification date: 2023-08-16) |
Primary citation | Long, S.B.,Hancock, P.J.,Kral, A.M.,Hellinga, H.W.,Beese, L.S. The crystal structure of human protein farnesyltransferase reveals the basis for inhibition by CaaX tetrapeptides and their mimetics. Proc.Natl.Acad.Sci.USA, 98:12948-12953, 2001 Cited by PubMed: 11687658DOI: 10.1073/pnas.241407898 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
Download full validation report