1J46
3D Solution NMR Structure of the Wild Type HMG-BOX Domain of the Human Male Sex Determining Factor Sry Complexed to DNA
Summary for 1J46
Entry DOI | 10.2210/pdb1j46/pdb |
Related | 1J47 |
Descriptor | 5'-D(*CP*CP*TP*GP*CP*AP*CP*AP*AP*AP*CP*AP*CP*C)-3', 5'-D(*GP*GP*TP*GP*TP*TP*TP*GP*TP*GP*CP*AP*GP*G)-3', SEX-DETERMINING REGION Y PROTEIN (3 entities in total) |
Functional Keywords | male sex determining factor, sry, sex-reversal mutation, dna bending mutant, dipolar couplings, multidimensional nmr, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus speckle: Q05066 |
Total number of polymer chains | 3 |
Total formula weight | 19216.15 |
Authors | Clore, G.M.,Murphy, E.C. (deposition date: 2001-07-23, release date: 2001-10-03, Last modification date: 2023-12-27) |
Primary citation | Murphy, E.C.,Zhurkin, V.B.,Louis, J.M.,Cornilescu, G.,Clore, G.M. Structural basis for SRY-dependent 46-X,Y sex reversal: modulation of DNA bending by a naturally occurring point mutation. J.Mol.Biol., 312:481-499, 2001 Cited by PubMed: 11563911DOI: 10.1006/jmbi.2001.4977 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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