1IRS
IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Summary for 1IRS
Entry DOI | 10.2210/pdb1irs/pdb |
Descriptor | IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE (2 entities in total) |
Functional Keywords | phosphotyrosine binding domain (ptb), complex, signal transduction, complex (signal transduction-peptide), complex (signal transduction-peptide) complex, complex (signal transduction/peptide) |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P24394 |
Total number of polymer chains | 2 |
Total formula weight | 13890.05 |
Authors | Zhou, M.-M.,Huang, B.,Olejniczak, E.T.,Meadows, R.P.,Shuker, S.B.,Miyazaki, M.,Trub, T.,Shoelson, S.E.,Feisk, S.W. (deposition date: 1996-03-22, release date: 1997-05-15, Last modification date: 2022-02-23) |
Primary citation | Zhou, M.M.,Huang, B.,Olejniczak, E.T.,Meadows, R.P.,Shuker, S.B.,Miyazaki, M.,Trub, T.,Shoelson, S.E.,Fesik, S.W. Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat.Struct.Biol., 3:388-393, 1996 Cited by PubMed: 8599766DOI: 10.1038/nsb0496-388 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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