1INW
A SIALIC ACID DERIVED PHOSPHONATE ANALOG INHIBITS DIFFERENT STRAINS OF INFLUENZA VIRUS NEURAMINIDASE WITH DIFFERENT EFFICIENCIES
Summary for 1INW
Entry DOI | 10.2210/pdb1inw/pdb |
Descriptor | INFLUENZA A SUBTYPE N2 NEURAMINIDASE, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | hydrolase, o-glycosyl, neuraminidase, sialidase |
Biological source | Influenza A virus |
Cellular location | Virion membrane (By similarity): P06820 |
Total number of polymer chains | 1 |
Total formula weight | 45084.78 |
Authors | White, C.L.,Janakiraman, M.N.,Laver, W.G.,Philippon, C.,Vasella, A.,Air, G.M.,Luo, M. (deposition date: 1994-09-26, release date: 1995-02-07, Last modification date: 2020-07-29) |
Primary citation | White, C.L.,Janakiraman, M.N.,Laver, W.G.,Philippon, C.,Vasella, A.,Air, G.M.,Luo, M. A sialic acid-derived phosphonate analog inhibits different strains of influenza virus neuraminidase with different efficiencies. J.Mol.Biol., 245:623-634, 1995 Cited by PubMed: 7844831DOI: 10.1006/jmbi.1994.0051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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