1I8J

CRYSTAL STRUCTURE OF PORPHOBILINOGEN SYNTHASE COMPLEXED WITH THE INHIBITOR 4,7-DIOXOSEBACIC ACID

Summary for 1I8J

Entry DOI	10.2210/pdb1i8j/pdb
Descriptor	PORPHOBILINOGEN SYNTHASE, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	lyase, heme biosynthesis, magnesium, 4, 7-dioxosebacic acid
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	71715.08
Authors	Kervinen, J.,Jaffe, E.K.,Stauffer, F.,Neier, R.,Wlodawer, A.,Zdanov, A. (deposition date: 2001-03-14, release date: 2001-06-20, Last modification date: 2023-08-09)
Primary citation	Kervinen, J.,Jaffe, E.K.,Stauffer, F.,Neier, R.,Wlodawer, A.,Zdanov, A. Mechanistic basis for suicide inactivation of porphobilinogen synthase by 4,7-dioxosebacic acid, an inhibitor that shows dramatic species selectivity. Biochemistry, 40:8227-8236, 2001 Cited by PubMed: 11444968 DOI: 10.1021/bi010656k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation