1HXB
HIV-1 proteinase complexed with RO 31-8959
Summary for 1HXB
Entry DOI | 10.2210/pdb1hxb/pdb |
Related PRD ID | PRD_000454 |
Descriptor | HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide (3 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, aspartyl protease, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus type 1 (CLONE 12) |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585 |
Total number of polymer chains | 2 |
Total formula weight | 22250.30 |
Authors | Graves, B.J.,Hatada, M.H.,Crowther, R.L. (deposition date: 1996-09-13, release date: 1997-03-12, Last modification date: 2024-02-07) |
Primary citation | Krohn, A.,Redshaw, S.,Ritchie, J.C.,Graves, B.J.,Hatada, M.H. Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere. J.Med.Chem., 34:3340-3342, 1991 Cited by PubMed: 1956054DOI: 10.1021/jm00115a028 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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