1HTG
X-RAY CRYSTALLOGRAPHIC STUDIES OF A SERIES OF PENICILLIN-DERIVED ASYMMETRIC INHIBITORS OF HIV-1 PROTEASE
Summary for 1HTG
Entry DOI | 10.2210/pdb1htg/pdb |
Descriptor | HIV-1 PROTEASE, 2-(BENZYLCARBAMOYL-PHENYLACETYLAMINO-METHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID 3-[(1H-BENZIMIDAZOL-2-YLMETHYLCARBAMOYL)-1-BENZYL-2-HYDROXYPROPYL]-AMIDE (3 entities in total) |
Functional Keywords | hydrolase(acid proteinase) |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 |
Total number of polymer chains | 2 |
Total formula weight | 23131.37 |
Authors | Jhoti, H.,Wonacott, A.,Murray-Rust, P. (deposition date: 1994-04-29, release date: 1994-07-31, Last modification date: 2024-02-07) |
Primary citation | Jhoti, H.,Singh, O.M.,Weir, M.P.,Cooke, R.,Murray-Rust, P.,Wonacott, A. X-ray crystallographic studies of a series of penicillin-derived asymmetric inhibitors of HIV-1 protease. Biochemistry, 33:8417-8427, 1994 Cited by PubMed: 8031777DOI: 10.1021/bi00194a005 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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