1GO4
Crystal structure of Mad1-Mad2 reveals a conserved Mad2 binding motif in Mad1 and Cdc20.
Summary for 1GO4
Entry DOI | 10.2210/pdb1go4/pdb |
Related | 1DUJ |
Descriptor | Mitotic spindle assembly checkpoint protein MAD2A, Mitotic spindle assembly checkpoint protein MAD1 (3 entities in total) |
Functional Keywords | mitotic spindle checkpoint, cell cycle, mitosis, nuclear pro |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 140563.48 |
Authors | Sironi, L.,Mapelli, M.,Jeang, K.T.,Musacchio, A. (deposition date: 2001-10-17, release date: 2002-05-16, Last modification date: 2023-12-13) |
Primary citation | Sironi, L.,Mapelli, M.,Knapp, S.,De Antoni, A.,Jeang, K.T.,Musacchio, A. Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint. EMBO J., 21:2496-2506, 2002 Cited by PubMed: 12006501DOI: 10.1093/emboj/21.10.2496 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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