1G2K

HIV-1 PROTEASE WITH CYCLIC SULFAMIDE INHIBITOR, AHA047

Summary for 1G2K

• Entry DOI: 10.2210/pdb1g2k/pdb
• Related: 1ajv 1ajx
• Descriptor: PROTEASE RETROPEPSIN, 3-(7-BENZYL-4,5-DIHYDROXY-1,1-DIOXO-3,6-BIS-PHENOXYMETHYL-1L6-[1,2,7]THIADIAZEPAN-2-YLMETHYL)-N-METHYL-BENZAMIDE (3 entities in total)
• Functional Keywords: hiv, protease inhibitors, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04587
• Total number of polymer chains: 2
• Total formula weight: 22239.25

Authors

Lindberg, J.,Unge, T. (deposition date: 2000-10-20, release date: 2001-06-01, Last modification date: 2023-08-09)

• Primary citation: Schaal, W.,Karlsson, A.,Ahlsen, G.,Lindberg, J.,Andersson, H.O.,Danielson, U.H.,Classon, B.,Unge, T.,Samuelsson, B.,Hulten, J.,Hallberg, A.,Karlen, A.; Synthesis and comparative molecular field analysis (CoMFA) of symmetric and nonsymmetric cyclic sulfamide HIV-1 protease inhibitors.; J.Med.Chem., 44:155-169, 2001; PubMed: 11170625; DOI: 10.1021/jm001024j

Experimental method

X-RAY DIFFRACTION (1.95 Å)