1FDP

PROENZYME OF HUMAN COMPLEMENT FACTOR D, RECOMBINANT PROFACTOR D

Summary for 1FDP

Entry DOI	10.2210/pdb1fdp/pdb
Descriptor	PROENZYME OF COMPLEMENT FACTOR D (2 entities in total)
Functional Keywords	serine protease, complement, factor d, profactor d, zymogen, proenzyme, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Secreted: P00746
Total number of polymer chains	4
Total formula weight	100586.53
Authors	Jing, H.,Macon, K.J.,Moore, D.,Delucas, L.J.,Volanakis, J.E.,Narayana, S.V.L. (deposition date: 1998-12-03, release date: 1999-12-03, Last modification date: 2023-08-09)
Primary citation	Jing, H.,Macon, K.J.,Moore, D.,DeLucas, L.J.,Volanakis, J.E.,Narayana, S.V. Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D. Embo J., 18:804-814, 1999 Cited by PubMed: 10022823 DOI: 10.1093/emboj/18.4.804 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation