1EX8
CRYSTAL STRUCTURE OF 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE COMPLEXED WITH HP4A, THE TWO-SUBSTRATE-MIMICKING INHIBITOR
Summary for 1EX8
Entry DOI | 10.2210/pdb1ex8/pdb |
Related | 1CBK 1DY3 1EQ0 1EQM 1EQO 1HKA |
Descriptor | 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total) |
Functional Keywords | pyrophosphokinase, pyrophosphoryl transfer, folate, hppk, pterin, atp, bisubstrate-mimicking inhibitor, antimicrobial agent, drug design, substrate specificity, active-site architecture, transferase |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 18790.62 |
Authors | Blaszczyk, J.,Ji, X. (deposition date: 2000-05-01, release date: 2001-05-01, Last modification date: 2023-08-30) |
Primary citation | Shi, G.,Blaszczyk, J.,Ji, X.,Yan, H. Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies. J.Med.Chem., 44:1364-1371, 2001 Cited by PubMed: 11311059DOI: 10.1021/jm0004493 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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