1DY8
Inhibition of the Hepatitis C Virus NS3/4A Protease. The Crystal Structures of Two Protease-Inhibitor Complexes (inhibitor II)
Summary for 1DY8
Entry DOI | 10.2210/pdb1dy8/pdb |
Related | 1DXP 1DY9 1JXP |
Related PRD ID | PRD_000271 |
Descriptor | PROTEASE/HELICASE NS3 (P70), NONSTRUCTURAL PROTEIN NS4A (P4), N-[(benzyloxy)carbonyl]-L-isoleucyl-N-[(1R)-1-(carboxycarbonyl)-3,3-difluoropropyl]-L-leucinamide, ... (4 entities in total) |
Functional Keywords | serine protease, protease inhibition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HEPATITIS C VIRUS (ISOLATE TAIWAN) More |
Total number of polymer chains | 4 |
Total formula weight | 43926.42 |
Authors | Di Marco, S.,Rizzi, M.,Volpari, C.,Walsh, M.,Narjes, F.,Colarusso, S.,De Francesco, R.,Matassa, V.G.,Sollazzo, M. (deposition date: 2000-01-31, release date: 2001-01-28, Last modification date: 2023-12-06) |
Primary citation | Di Marco, S.,Rizzi, M.,Volpari, C.,Walsh, M.,Narjes, F.,Colarusso, S.,De Francesco, R.,Matassa, V.G.,Sollazzo, M. Inhibition of the Hepatitis C Virus Ns3/4A Protease the Crystal Structures of Two Protease-Inhibitor Complexes J.Biol.Chem., 275:7152-, 2000 Cited by PubMed: 10702283DOI: 10.1074/JBC.275.10.7152 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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