1DQA
COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH HMG, COA, AND NADP+
Summary for 1DQA
Entry DOI | 10.2210/pdb1dqa/pdb |
Descriptor | PROTEIN (HMG-COA REDUCTASE), COENZYME A, 3-HYDROXY-3-METHYL-GLUTARIC ACID, ... (5 entities in total) |
Functional Keywords | oxidoreductase, cholesterol biosynthesis, hmg-coa, nadph |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: P04035 |
Total number of polymer chains | 4 |
Total formula weight | 206778.41 |
Authors | Istvan, E.S.,Palnitkar, M.,Buchanan, S.K.,Deisenhofer, J. (deposition date: 1999-12-30, release date: 2000-03-08, Last modification date: 2024-02-07) |
Primary citation | Istvan, E.S.,Palnitkar, M.,Buchanan, S.K.,Deisenhofer, J. Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into regulation of activity and catalysis. EMBO J., 19:819-830, 2000 Cited by PubMed: 10698924DOI: 10.1093/emboj/19.5.819 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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