1D5R
Crystal Structure of the PTEN Tumor Suppressor
Summary for 1D5R
Entry DOI | 10.2210/pdb1d5r/pdb |
Descriptor | PHOSPHOINOSITIDE PHOSPHATASE PTEN, L(+)-TARTARIC ACID (3 entities in total) |
Functional Keywords | c2 domain, phosphotidylinositol, phosphatase, hydrolase |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm . Isoform alpha: Secreted : P60484 |
Total number of polymer chains | 1 |
Total formula weight | 38646.27 |
Authors | Lee, J.O.,Yang, H.,Georgescu, M.-M.,Di Cristofano, A.,Pavletich, N.P. (deposition date: 1999-10-11, release date: 1999-11-04, Last modification date: 2024-02-07) |
Primary citation | Lee, J.O.,Yang, H.,Georgescu, M.M.,Di Cristofano, A.,Maehama, T.,Shi, Y.,Dixon, J.E.,Pandolfi, P.,Pavletich, N.P. Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell(Cambridge,Mass.), 99:323-334, 1999 Cited by PubMed: 10555148DOI: 10.1016/S0092-8674(00)81663-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report