1CJ1
GROWTH FACTOR RECEPTOR BINDING PROTEIN SH2 DOMAIN (HUMAN) COMPLEXED WITH A PHOSPHOTYROSYL DERIVATIVE
Summary for 1CJ1
Entry DOI | 10.2210/pdb1cj1/pdb |
Descriptor | PROTEIN (GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2), [1-[1-(6-CARBAMOYL-CYCLOHEX-2-ENYLCARBAMOYL)-CYCLOHEXYLCARBAMOYL]-2-(4-PHOSPHONOOXY-PHENYL)- ETHYL]-CARBAMIC ACID 3-AMINOBENZYLESTER (3 entities in total) |
Functional Keywords | signal transduction, sh2 domain, phosphotyrosine, signaling protein |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus : P62993 |
Total number of polymer chains | 12 |
Total formula weight | 142155.80 |
Authors | Rahuel, J. (deposition date: 1999-04-21, release date: 1999-12-22, Last modification date: 2023-08-02) |
Primary citation | Furet, P.,Garcia-Echeverria, C.,Gay, B.,Schoepfer, J.,Zeller, M.,Rahuel, J. Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic. J.Med.Chem., 42:2358-2363, 1999 Cited by PubMed: 10395476DOI: 10.1021/jm991013u PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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