1BV7
COUNTERACTING HIV-1 PROTEASE DRUG RESISTANCE: STRUCTURAL ANALYSIS OF MUTANT PROTEASES COMPLEXED WITH XV638 AND SD146, CYCLIC UREA AMIDES WITH BROAD SPECIFICITIES
Summary for 1BV7
Entry DOI | 10.2210/pdb1bv7/pdb |
Descriptor | PROTEIN (HIV-1 PROTEASE), [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-3,3'-[[TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-D IYL] BIS(METHYLENE)]BIS[N-2-THIAZOLYLBENZAMIDE] (3 entities in total) |
Functional Keywords | hydrolase(acid proteinase), hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
Total number of polymer chains | 2 |
Total formula weight | 22434.45 |
Authors | Ala, P.,Chang, C.H. (deposition date: 1998-09-22, release date: 1998-09-30, Last modification date: 2024-02-07) |
Primary citation | Ala, P.J.,Huston, E.E.,Klabe, R.M.,Jadhav, P.K.,Lam, P.Y.,Chang, C.H. Counteracting HIV-1 protease drug resistance: structural analysis of mutant proteases complexed with XV638 and SD146, cyclic urea amides with broad specificities. Biochemistry, 37:15042-15049, 1998 Cited by PubMed: 9790666DOI: 10.1021/bi980386e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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