1BA8

THROMBIN INHIBITOR WITH A RIGID TRIPEPTIDYL ALDEHYDES

Summary for 1BA8

Entry DOI	10.2210/pdb1ba8/pdb
Related PRD ID	PRD_000322
Descriptor	THROMBIN, HIRUGEN, amino({(4S)-4-[({(3S)-3-[(benzylsulfonyl)amino]-2-oxopiperidin-1-yl}acetyl)amino]-5-oxopentyl}amino)methaniminium, ... (6 entities in total)
Functional Keywords	hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Hirudo medicinalis (medicinal leech) More
Total number of polymer chains	3
Total formula weight	36127.10
Authors	Krishnan, R.,Zhang, E.,Hakansson, K.,Arni, R.K.,Tulinsky, A.,Lim-Wilby, M.S.L.,Levy, O.E.,Semple, J.E.,Brunck, T.K. (deposition date: 1998-04-23, release date: 1999-04-27, Last modification date: 2023-08-02)
Primary citation	Krishnan, R.,Zhang, E.,Hakansson, K.,Arni, R.K.,Tulinsky, A.,Lim-Wilby, M.S.,Levy, O.E.,Semple, J.E.,Brunck, T.K. Highly selective mechanism-based thrombin inhibitors: structures of thrombin and trypsin inhibited with rigid peptidyl aldehydes. Biochemistry, 37:12094-12103, 1998 Cited by PubMed: 9724521 DOI: 10.1021/bi980840e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation