1B5G

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

Summary for 1B5G

Entry DOI	10.2210/pdb1b5g/pdb
Descriptor	ALPHA-THROMBIN, HIRUGEN, [[[(4S,5S)-4-[[(3S,6S,8aR)-6-azanyl-5-oxo-6-(phenylmethyl)-1,2,3,7,8,8a-hexahydroindolizin-3-yl]carbonylamino]-5-(1,3-benzothiazol-2-yl)-5-hydroxy-pentyl]amino]-azanyl-methylidene]azanium, ... (6 entities in total)
Functional Keywords	serine protease-inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P09945 Secreted: P00734
Total number of polymer chains	3
Total formula weight	36022.01
Authors	St Charles, R.,Tulinsky, A.,Kahn, M. (deposition date: 1998-03-05, release date: 1998-05-27, Last modification date: 2015-03-25)
Primary citation	St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A. Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin. J.Med.Chem., 42:1376-1383, 1999 Cited by PubMed: 10212123 DOI: 10.1021/jm980052n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.07 Å)

Structure validation