1AWH
NOVEL COVALENT THROMBIN INHIBITOR FROM PLANT EXTRACT
Summary for 1AWH
Entry DOI | 10.2210/pdb1awh/pdb |
Descriptor | ALPHA THROMBIN, 3-ACETOXY-17-(1-FORMYL-5-METHYL-3-OXO-HEX-4-ENYL)-16-HYDROXY-4,10,13,14-TETRAMETHYL-2,3,4,5,6,9,10,11,12,13,14,15,16,17-TETRADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE-4-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | proteinase, blood coagulation, trypsin like proteinase, complex (protease-inhibitor), complex (protease-inhibitor) complex, complex (protease/inhibitor) |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 4 |
Total formula weight | 68838.91 |
Authors | Jhoti, H.,Cleasby, A.,Wonacott, A. (deposition date: 1997-10-02, release date: 1998-10-28, Last modification date: 2024-04-03) |
Primary citation | Weir, M.P.,Bethell, S.S.,Cleasby, A.,Campbell, C.J.,Dennis, R.J.,Dix, C.J.,Finch, H.,Jhoti, H.,Mooney, C.J.,Patel, S.,Tang, C.M.,Ward, M.,Wonacott, A.J.,Wharton, C.W. Novel natural product 5,5-trans-lactone inhibitors of human alpha-thrombin: mechanism of action and structural studies. Biochemistry, 37:6645-6657, 1998 Cited by PubMed: 9578548DOI: 10.1021/bi972499o PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
Download full validation report