1ATK
CRYSTAL STRUCTURE OF THE CYSTEINE PROTEASE HUMAN CATHEPSIN K IN COMPLEX WITH THE COVALENT INHIBITOR E-64
Summary for 1ATK
Entry DOI | 10.2210/pdb1atk/pdb |
Descriptor | CATHEPSIN K, N-[N-[1-HYDROXYCARBOXYETHYL-CARBONYL]LEUCYLAMINO-BUTYL]-GUANIDINE (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 23883.91 |
Authors | Zhao, B.,Smith, W.W.,Janson, C.A.,Abdel-Meguid, S.S. (deposition date: 1996-12-19, release date: 1998-02-04, Last modification date: 2023-08-02) |
Primary citation | Zhao, B.,Janson, C.A.,Amegadzie, B.Y.,D'Alessio, K.,Griffin, C.,Hanning, C.R.,Jones, C.,Kurdyla, J.,McQueney, M.,Qiu, X.,Smith, W.W.,Abdel-Meguid, S.S. Crystal structure of human osteoclast cathepsin K complex with E-64. Nat.Struct.Biol., 4:109-111, 1997 Cited by PubMed: 9033588DOI: 10.1038/nsb0297-109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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