8XMN

Voltage-gated sodium channel Nav1.7 variant M2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Sodium channel protein type 9 subunit alpha	polymer	2031	231292.0	1	UniProt (Q15858) Pfam (PF00520) Pfam (PF11933) Pfam (PF06512) In PDB	Homo sapiens (human)	Neuroendocrine sodium channel,hNE-Na,Peripheral sodium channel 1,PN1,Sodium channel protein type IX subunit alpha,Voltage-gated sodium channel subunit alpha Nav1.7
2	B	Sodium channel subunit beta-1	polymer	230	26355.9	1	UniProt (Q07699) Pfam (PF07686) In PDB	Homo sapiens (human)
3	C	Sodium channel subunit beta-2	polymer	227	25979.6	1	UniProt (O60939) Pfam (PF07686) In PDB	Homo sapiens (human)
4	D, E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
5	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	6	Chemie (NAG)
6	A	1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		510.7	5	Chemie (LPE)
7	A	1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		787.1	3	Chemie (PCW)

Sequence modifications

A: 1 - 1988 (UniProt: Q15858)

PDB	External Database	Details
Met -42	-	initiating methionine
Ala -41	-	expression tag
Ser -40	-	expression tag
Trp -39	-	expression tag
Ser -38	-	expression tag
His -37	-	expression tag
Pro -36	-	expression tag
Gln -35	-	expression tag
Phe -34	-	expression tag
Glu -33	-	expression tag
Lys -32	-	expression tag
Gly -31	-	expression tag
Gly -30	-	expression tag
Gly -29	-	expression tag
Ala -28	-	expression tag
Arg -27	-	expression tag
Gly -26	-	expression tag
Gly -25	-	expression tag
Ser -24	-	expression tag
Gly -23	-	expression tag
Gly -22	-	expression tag
Gly -21	-	expression tag
Ser -20	-	expression tag
Trp -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
Pro -16	-	expression tag
Gln -15	-	expression tag
Phe -14	-	expression tag
Glu -13	-	expression tag
Lys -12	-	expression tag
Gly -11	-	expression tag
Phe -10	-	expression tag
Asp -9	-	expression tag
Tyr -8	-	expression tag
Lys -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Lys -2	-	expression tag
Gly -1	-	expression tag
Thr 0	-	expression tag
Phe 866	Leu 866	variant
Cys 1454	Gly 1454	variant

B: 1 - 218 (UniProt: Q07699)

PDB	External Database	Details
Leu 219	-	expression tag
Glu 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag
His 228	-	expression tag
His 229	-	expression tag
His 230	-	expression tag

C: 1 - 215 (UniProt: O60939)

PDB	External Database	Details
Leu 216	-	expression tag
Glu 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag
His 220	-	expression tag
His 221	-	expression tag
His 222	-	expression tag
His 223	-	expression tag
His 224	-	expression tag
His 225	-	expression tag
His 226	-	expression tag
His 227	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	283627.4
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	14
	Total formula weight	6242.2
All*	Total formula weight	290718.4

*Water molecules are not included.