8UH0
SOS2 co-crystal structure with fragment bound (compound 10)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Son of sevenless homolog 2 | polymer | 484 | 56773.0 | 1 | UniProt (Q07890) Pfam (PF00618) Pfam (PF00617) In PDB | Homo sapiens (human) | SOS-2 |
2 | A | 8-hydroxyquinoline-2-carbonitrile | non-polymer | 170.2 | 1 | Chemie (WRN) | |||
3 | water | water | 18.0 | 63 | Chemie (HOH) |
Sequence modifications
A: 565 - 1041 (UniProt: Q07890)
PDB | External Database | Details |
---|---|---|
Gly 558 | - | expression tag |
Ala 559 | - | expression tag |
Met 560 | - | expression tag |
Ala 561 | - | expression tag |
Glu 562 | - | expression tag |
Gln 563 | - | expression tag |
Gln 564 | - | expression tag |
Tyr 707 | Glu 707 | conflict |
His 768 | Gln 768 | conflict |
Ile 769 | Phe 769 | conflict |
Thr 947 | Lys 947 | conflict |
Arg 948 | Lys 948 | conflict |
His 949 | Lys 949 | conflict |
Pro 1019 | Cys 1019 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 56773.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 170.2 | |
All* | Total formula weight | 56943.2 |