8TZ9

Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with Molnupiravir, condition 2, INT2-INT2-INT2 conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A, C	Sodium/nucleoside cotransporter	polymer	715	79376.8	3	UniProt (F1MGR1) Pfam (PF01773) Pfam (PF07670) Pfam (PF07662) In PDB	Bos taurus (cattle)
2	B, A, C	N-hydroxy-5'-O-(2-methylpropanoyl)cytidine	non-polymer		329.3	3	Chemie (XMO)

Sequence modifications

B, A, C: 1 - 697 (UniProt: F1MGR1)

PDB	External Database	Details
Met -14	-	initiating methionine
Asp -13	-	expression tag
Tyr -12	-	expression tag
Lys -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Asp -7	-	expression tag
Lys -6	-	expression tag
Leu -5	-	expression tag
Glu -4	-	expression tag
Ala -3	-	expression tag
Thr -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
Ser 698	-	expression tag
Asn 699	-	expression tag
Ser 700	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	238130.3
Non-Polymers*	Number of molecules	3
	Total formula weight	987.9
All*	Total formula weight	239118.2

*Water molecules are not included.