8TZ4

Cryo-EM structure of bovine concentrative nucleoside transporter 3 in complex with GS-441524, subset reconstruction

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, B	Sodium/nucleoside cotransporter	polymer	715	79376.8	3	UniProt (F1MGR1) Pfam (PF01773) Pfam (PF07670) Pfam (PF07662) In PDB	Bos taurus (cattle)
2	A	(2~{R},3~{R},4~{S},5~{R})-2-(4-azanylpyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolane-2-carbonitrile	non-polymer		291.3	1	Chemie (U08)

Sequence modifications

A, C, B: 1 - 697 (UniProt: F1MGR1)

PDB	External Database	Details
Met -14	-	initiating methionine
Asp -13	-	expression tag
Tyr -12	-	expression tag
Lys -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Asp -7	-	expression tag
Lys -6	-	expression tag
Leu -5	-	expression tag
Glu -4	-	expression tag
Ala -3	-	expression tag
Thr -2	-	expression tag
Met -1	-	expression tag
Ala 0	-	expression tag
Ser 698	-	expression tag
Asn 699	-	expression tag
Ser 700	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	238130.3
Non-Polymers*	Number of molecules	1
	Total formula weight	291.3
All*	Total formula weight	238421.6

*Water molecules are not included.