8P7J
Crystal structure of MAP2K6 with a covalent compound GCL96
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Dual specificity mitogen-activated protein kinase kinase 6 | polymer | 290 | 32749.9 | 2 | UniProt (P52564) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase kinase 6,MAPKK 6,MAPK/ERK kinase 6,MEK 6,Stress-activated protein kinase kinase 3,SAPK kinase 3,SAPKK-3,SAPKK3 |
| 2 | A, B | N-[3-(1H-pyrrolo[2,3-b]pyridin-4-yl)phenyl]prop-2-enamide | non-polymer | 263.3 | 2 | Chemie (X3K) | |||
| 3 | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, B: 47 - 334 (UniProt: P52564)
| PDB | External Database | Details |
|---|---|---|
| Ser 45 | - | expression tag |
| Met 46 | - | expression tag |
| Asp 207 | Ser 207 | engineered mutation |
| Asp 211 | Thr 211 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65499.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 526.6 | |
| All* | Total formula weight | 66026.4 |
