8GS5
Crystal structure of a constitutively active mutant of human IDH3 holoenzyme in apo form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C, A, G, E, K... | Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | polymer | 339 | 36625.1 | 8 | UniProt (P50213) Pfam (PF00180) In PDB | Homo sapiens (human) | Isocitric dehydrogenase subunit alpha,NAD(+)-specific ICDH subunit alpha |
2 | D, H, L, P | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial | polymer | 354 | 38867.5 | 4 | UniProt (P51553) Pfam (PF00180) In PDB | Homo sapiens (human) | NAD-IDH gamma subunit, Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma |
3 | B, F, J, N | Isoform A of Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | polymer | 352 | 39152.0 | 4 | UniProt (O43837-2) Pfam (PF00180) UniProt (by SIFTS) (O43837) In PDB | Homo sapiens (human) | Isocitric dehydrogenase subunit beta,NAD(+)-specific ICDH subunit beta |
Sequence modifications
C, A, G, E, K, I, O, M: 1 - 339 (UniProt: P50213)
B, F, J, N: 1 - 340 (UniProt: O43837-2)
PDB | External Database | Details |
---|---|---|
Ala 139 | Gln 166 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 341 | - | expression tag |
Ile 342 | - | expression tag |
Cys 343 | - | expression tag |
Arg 344 | - | expression tag |
Arg 345 | - | expression tag |
Val 346 | - | expression tag |
Lys 347 | - | expression tag |
Asp 348 | - | expression tag |
Leu 349 | - | expression tag |
Asp 350 | - | expression tag |
Glu 351 | - | expression tag |
Asn 352 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 16 |
Total formula weight | 605079.2 | |
All* | Total formula weight | 605079.2 |