8FY3

Structure of NOT1:NOT10:NOT11 module of the human CCR4-NOT complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	CCR4-NOT transcription complex subunit 1	polymer	1000	111576.8	1	UniProt (A5YKK6) Pfam (PF16418) Pfam (PF16417) In PDB	Homo sapiens (human)	CCR4-associated factor 1,Negative regulator of transcription subunit 1 homolog,NOT1H,hNOT1
2	B	CCR4-NOT transcription complex subunit 10	polymer	684	75931.1	1	UniProt (Q9H9A5) In PDB	Homo sapiens (human)
3	C	CCR4-NOT transcription complex subunit 11	polymer	269	30362.1	1	UniProt (B3KNB0) Pfam (PF10155) UniProt (by SIFTS) (Q9UKZ1) In PDB	Homo sapiens (human)

Sequence modifications

B: 25 - 707 (UniProt: Q9H9A5)

PDB	External Database	Details
Met 24	-	initiating methionine

C: 257 - 498 (UniProt: B3KNB0)

PDB	External Database	Details
Met 256	-	initiating methionine
Gly 499	-	expression tag
Ser 500	-	expression tag
Glu 501	-	expression tag
Asn 502	-	expression tag
Leu 503	-	expression tag
Tyr 504	-	expression tag
Phe 505	-	expression tag
Gln 506	-	expression tag
Gly 507	-	expression tag
Ser 508	-	expression tag
Gly 509	-	expression tag
Ala 510	-	expression tag
Met 511	-	expression tag
Gly 512	-	expression tag
Ser 513	-	expression tag
Gly 514	-	expression tag
Ser 515	-	expression tag
Gly 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag
His 522	-	expression tag
Gly 523	-	expression tag
Thr 524	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	217870.1
All*	Total formula weight	217870.1

*Water molecules are not included.