8FXS
Crystal structure of human pro-TGF-beta2 in complex with Nb9
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transforming growth factor beta-2 proprotein | polymer | 393 | 45195.4 | 2 | UniProt (P61812) Pfam (PF00688) Pfam (PF00019) In PDB | Homo sapiens (human) | Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF |
2 | D, E | Nanobody clone 9 | polymer | 124 | 13802.2 | 2 | synthetic construct | ||
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
4 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A, B: 21 - 410 (UniProt: P61812)
PDB | External Database | Details |
---|---|---|
Gly 18 | - | expression tag |
Pro 19 | - | expression tag |
Ser 20 | - | expression tag |
Ser 24 | Cys 24 | engineered mutation |
Arg 140 | Asn 140 | engineered mutation |
Gly 298 | Arg 298 | engineered mutation |
- | Arg 299 | deletion |
- | Lys 300 | deletion |
- | Lys 301 | deletion |
- | Arg 302 | deletion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 117995.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 442.4 | |
All* | Total formula weight | 118437.7 |