8F87
Crystal structure of Ebola Zaire envelope glycoprotein GP in complex with compound ARN75092
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | GP1 | polymer | 291 | 32309.3 | 1 | UniProt (Q05320) Pfam (PF01611) In PDB | Ebola virus - Mayinga Zaire 1976 | |
| 2 | B | GP2 | polymer | 168 | 18922.3 | 1 | UniProt (Q05320) In PDB | Ebola virus - Mayinga Zaire 1976 | |
| 3 | C | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | A | [(4S)-4-amino-3,3-dimethylpiperidin-1-yl][(1S,3R,5R,7S)-3-methyl-5-phenyladamantan-1-yl]methanone | non-polymer | 380.6 | 1 | Chemie (XJ5) | |||
| 6 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | water | water | 18.0 | 11 | Chemie (HOH) |
Sequence modifications
A: 32 - 357 (UniProt: Q05320)
B: 502 - 632 (UniProt: Q05320)
| PDB | External Database | Details |
|---|---|---|
| Glu 28 | - | cloning artifact |
| Thr 29 | - | cloning artifact |
| Gly 30 | - | cloning artifact |
| Arg 31 | - | cloning artifact |
| Ala 42 | Thr 42 | engineered mutation |
| Unk 352 | Asn 313 | conflict |
| Unk 353 | Gly 314 | conflict |
| Unk 354 | Ala 315 | conflict |
| Unk 355 | Lys 316 | conflict |
| Unk 356 | Asn 317 | conflict |
| Unk 357 | Ile 318 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 613 | His 613 | engineered mutation |
| Gly 633 | - | expression tag |
| Ser 634 | - | expression tag |
| Gly 635 | - | expression tag |
| Tyr 636 | - | expression tag |
| Ile 637 | - | expression tag |
| Pro 638 | - | expression tag |
| Glu 639 | - | expression tag |
| Ala 640 | - | expression tag |
| Pro 641 | - | expression tag |
| Arg 642 | - | expression tag |
| Asp 643 | - | expression tag |
| Gly 644 | - | expression tag |
| Gln 645 | - | expression tag |
| Ala 646 | - | expression tag |
| Tyr 647 | - | expression tag |
| Val 648 | - | expression tag |
| Arg 649 | - | expression tag |
| Lys 650 | - | expression tag |
| Asp 651 | - | expression tag |
| Gly 652 | - | expression tag |
| Glu 653 | - | expression tag |
| Trp 654 | - | expression tag |
| Val 655 | - | expression tag |
| Leu 656 | - | expression tag |
| Leu 657 | - | expression tag |
| Ser 658 | - | expression tag |
| Thr 659 | - | expression tag |
| Phe 660 | - | expression tag |
| Leu 661 | - | expression tag |
| Gly 662 | - | expression tag |
| Thr 663 | - | expression tag |
| His 664 | - | expression tag |
| His 665 | - | expression tag |
| His 666 | - | expression tag |
| His 667 | - | expression tag |
| His 668 | - | expression tag |
| His 669 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51231.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1357.5 | |
| All* | Total formula weight | 53499.9 |
