8F4V
Alpha7 nicotinic acetylcholine receptor intracellular and transmembrane domains bound to ivermectin in a desensitized state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Neuronal acetylcholine receptor subunit alpha-7 | polymer | 272 | 29831.8 | 5 | UniProt (P36544) Pfam (PF02932) In PDB | Homo sapiens (human) | |
| 2 | A, B, C, D | (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside | non-polymer | 875.1 | 5 | Chemie (IVM) |
Sequence modifications
A, B, C, D, E: 209 - 474 (UniProt: P36544)
| PDB | External Database | Details |
|---|---|---|
| Ser 203 | - | expression tag |
| Asn 204 | - | expression tag |
| Ala 205 | - | expression tag |
| Glu 206 | - | expression tag |
| Glu 207 | - | expression tag |
| Glu 208 | - | expression tag |
| Ser 263 | Ala 285 | engineered mutation |
| Ser 268 | Val 290 | engineered mutation |
| Ser 270 | Leu 292 | engineered mutation |
| Glu 474 | Ala 496 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 149158.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 4375.5 | |
| All* | Total formula weight | 153534.4 |
