8EXU
Crystal structure of PI3K-alpha in complex with compound 30
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 1080 | 125951.3 | 1 | UniProt (P42336) Pfam (PF02192) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | PI3-kinase subunit alpha,PI3K-alpha,PI3Kalpha,PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,PtdIns-3-kinase subunit p110-alpha,p110alpha,Phosphoinositide 3-kinase alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
| 2 | A | (2S)-2-cyclopropyl-2-({(4S,11aM)-2-[(4S)-2-oxo-4-(trifluoromethyl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}amino)acetamide | non-polymer | 451.4 | 1 | Chemie (X3R) | |||
| 3 | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A: 0 - 1052 (UniProt: P42336)
| PDB | External Database | Details |
|---|---|---|
| Met -27 | - | initiating methionine |
| Ser -26 | - | expression tag |
| Tyr -25 | - | expression tag |
| Tyr -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| His -18 | - | expression tag |
| Asp -17 | - | expression tag |
| Tyr -16 | - | expression tag |
| Asp -15 | - | expression tag |
| Ile -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Thr -12 | - | expression tag |
| Thr -11 | - | expression tag |
| Glu -10 | - | expression tag |
| Asn -9 | - | expression tag |
| Leu -8 | - | expression tag |
| Tyr -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Glu 99 | - | insertion |
| Asn 100 | - | insertion |
| Leu 101 | - | insertion |
| Tyr 102 | - | insertion |
| Phe 103 | - | insertion |
| Gln 104 | - | insertion |
| Gly 105 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 125951.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 451.4 | |
| All* | Total formula weight | 126402.7 |
