8EQ5
Crystal structure of the N-terminal kinase domain of RSK2 in complex with SPRED2 (131-160)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Ribosomal protein S6 kinase alpha-3 | polymer | 305 | 35070.8 | 1 | UniProt (P51812) Pfam (PF00069) In PDB | Homo sapiens (human) | S6K-alpha-3,90 kDa ribosomal protein S6 kinase 3,p90-RSK 3,p90RSK3,Insulin-stimulated protein kinase 1,ISPK-1,MAP kinase-activated protein kinase 1b,MAPK-activated protein kinase 1b,MAPKAP kinase 1b,MAPKAPK-1b,Ribosomal S6 kinase 2,RSK-2,pp90RSK2 |
| 2 | B | Sprouty-related, EVH1 domain-containing protein 2 | polymer | 30 | 3245.3 | 1 | UniProt (Q7Z698) In PDB | Homo sapiens | Spred-2 |
| 3 | A | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl 6-deoxy-alpha-L-mannopyranoside | non-polymer | 448.4 | 1 | Chemie (QCT) | |||
| 4 | water | water | 18.0 | 139 | Chemie (HOH) |
Sequence modifications
A: 46 - 346 (UniProt: P51812)
| PDB | External Database | Details |
|---|---|---|
| Gly 42 | - | expression tag |
| Ala 43 | - | expression tag |
| Met 44 | - | expression tag |
| Gly 45 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38316.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 448.4 | |
| All* | Total formula weight | 38764.5 |
