8ENJ

Design, synthesis, biological evaluation, and X-ray crystallography of diarylpyrazole derivatives possessing terminal arylsulfonamide moieties as anti-proliferative agents targeting c-Jun N-terminal kinase (JNK)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 10	polymer	464	52649.3	1	UniProt (P53779) Pfam (PF00069) In PDB	Homo sapiens (human)	MAPK 10,MAP kinase p49 3F12,Stress-activated protein kinase 1b,SAPK1b,Stress-activated protein kinase JNK3,c-Jun N-terminal kinase 3
2	A	N-[3-({(4P)-4-[(3M)-1-tert-butyl-3-(3-hydroxyphenyl)-1H-pyrazol-4-yl]pyridin-2-yl}amino)propyl]-4-hydroxybenzene-1-sulfonamide	non-polymer		521.6	1	Chemie (WNK)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	52649.3
Non-Polymers*	Number of molecules	1
	Total formula weight	521.6
All*	Total formula weight	53171.0

*Water molecules are not included.