8E4R
Room-temperature X-ray structure of SARS-CoV-2 main protease H41A miniprecursor mutant in complex with GC373
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Replicase polyprotein 1ab | polymer | 314 | 34503.3 | 2 | UniProt (P0DTD1) Pfam (PF05409) In PDB | Severe acute respiratory syndrome coronavirus 2 | pp1ab,ORF1ab polyprotein |
| 2 | A, B | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid | non-polymer | 485.6 | 2 | Chemie (K36) | |||
| 3 | water | water | 18.0 | 205 | Chemie (HOH) |
Sequence modifications
A, B: -5 - 306 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser -7 | - | expression tag |
| Gly -6 | - | expression tag |
| Glu 0 | Gln 3263 | engineered mutation |
| Ala 41 | His 3304 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69006.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 971.1 | |
| All* | Total formula weight | 69977.6 |
