8E1X
FGFR2 kinase domain in complex with a Pyrazolo[1,5-a]pyrimidine analog (Compound 29)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Fibroblast growth factor receptor 2 | polymer | 330 | 37823.2 | 2 | UniProt (P21802) Pfam (PF07714) In PDB | Homo sapiens (human) | FGFR-2,K-sam,KGFR,Keratinocyte growth factor receptor |
2 | A, B | (5M)-N-methyl-5-{(6M,8S)-5-{[(3S)-oxolan-3-yl]amino}-6-[1-(propan-2-yl)-1H-pyrazol-3-yl]pyrazolo[1,5-a]pyrimidin-3-yl}pyridine-3-carboxamide | non-polymer | 446.5 | 2 | Chemie (U9P) | |||
3 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 768 (UniProt: P21802)
PDB | External Database | Details |
---|---|---|
Met 439 | - | initiating methionine |
Gly 440 | - | expression tag |
Ser 441 | - | expression tag |
Ser 442 | - | expression tag |
His 443 | - | expression tag |
His 444 | - | expression tag |
His 445 | - | expression tag |
His 446 | - | expression tag |
His 447 | - | expression tag |
His 448 | - | expression tag |
Ser 449 | - | expression tag |
Ser 450 | - | expression tag |
Gly 451 | - | expression tag |
Leu 452 | - | expression tag |
Val 453 | - | expression tag |
Pro 454 | - | expression tag |
Arg 455 | - | expression tag |
Gly 456 | - | expression tag |
Ser 457 | - | expression tag |
His 458 | - | expression tag |
Ala 491 | Cys 491 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 75646.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 893.0 | |
All* | Total formula weight | 76539.4 |