8DYJ

Crystal structure of human methylmalonyl-CoA mutase in complex with ADP and cob(II)alamin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Methylmalonyl-CoA mutase, mitochondrial	polymer	762	84835.8	1	UniProt (P22033) Pfam (PF01642) Pfam (PF02310) In PDB	Homo sapiens (human)	MCM,Methylmalonyl-CoA isomerase
2	B	COBALAMIN	non-polymer		1330.4	1	Chemie (B12)
3	B	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
4		water	water		18.0	121	Chemie (HOH)

Sequence modifications

B: -25 - 713 (UniProt: P22033)

PDB	External Database	Details
Met -26	-	initiating methionine
Thr 462	Ala 499	conflict
Val 634	Ile 671	conflict
Ala 714	-	expression tag
Glu 715	-	expression tag
Asn 716	-	expression tag
Leu 717	-	expression tag
Tyr 718	-	expression tag
Phe 719	-	expression tag
Gln 720	-	expression tag
Ser 721	-	expression tag
His 722	-	expression tag
His 723	-	expression tag
His 724	-	expression tag
His 725	-	expression tag
His 726	-	expression tag
His 727	-	expression tag
Asp 728	-	expression tag
Tyr 729	-	expression tag
Lys 730	-	expression tag
Asp 731	-	expression tag
Asp 732	-	expression tag
Asp 733	-	expression tag
Asp 734	-	expression tag
Lys 735	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	84835.8
Non-Polymers*	Number of molecules	2
	Total formula weight	1757.6
All*	Total formula weight	86593.4

*Water molecules are not included.