8DY5
Crystal Structure of spFv CAT2200 LH in complex with IL-17A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | spFv CAT2200 LH | polymer | 251 | 26521.3 | 2 | Homo sapiens | ||
| 2 | C, D | Interleukin-17A | polymer | 122 | 14209.9 | 2 | UniProt (Q16552) Pfam (PF06083) In PDB | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 4 | B | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | D | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 286 | Chemie (HOH) |
Sequence modifications
C, D: 12 - 132 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | initiating methionine |
| Gln 70 | Lys 93 | engineered mutation |
| Ser 106 | Cys 129 | engineered mutation |
| Gln 132 | Ala 155 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81462.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 99.8 | |
| All* | Total formula weight | 81562.2 |
